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COVID-19, SARS and MERS: are they closely related?
Petrosillo Nicola.
Viceconte Giulio.
Ergonul Onder.
Ippolito Giuseppe.
Petersen Eskild.
Acceso Abierto
Atribución-NoComercial-SinDerivadas
10.1016/j.cmi.2020.03.026
BACKGROUND:The 2019 novel coronavirus (SARS-CoV-2) is a new human coronavirus which is spreading with epidemic features in China and other Asian countries with cases reported worldwide. This novel Coronavirus Disease (COVID-19) is associated with a respiratory illness that may cause severe pneumonia and acute respiratory distress syndrome (ARDS). Although related to the Severe Acute Respiratory Syndrome (SARS) and the Middle East Respiratory Syndrome (MERS), COVID-19 shows some peculiar pathogenetic, epidemiological and clinical features which have not been completely understood to date. OBJECTIVES:We provide a review of the differences in terms of pathogenesis, epidemiology and clinical features between COVID-19, SARS and MERS. SOURCES:The most recent literature in English language regarding COVID-19 has been reviewed and extracted data have been compared with the current scientific evidence about SARS and MERS epidemics. CONTENT:COVID-19 seems not to be very different from SARS regarding its clinical features. However, it has a fatality rate of 2.3%, lower than SARS (9.5%) and much lower than MERS (34.4%). It cannot be excluded that because of the COVID-19 less severe clinical picture it can spread in the community more easily than MERS and SARS. The actual basic reproductive number (R0) of COVID-19 (2-2.5) is still controversial. It is probably slightly higher than the R0 of SARS (1.7-1.9) and higher than MERS (
Clinical Microbiology and Infection
2020
Artículo
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176926/pdf/main.pdf
Inglés
VIRUS RESPIRATORIOS
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