Por favor, use este identificador para citar o enlazar este ítem: http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/5321
ACE2 Expression is Increased in the Lungs of Patients with Comorbidities Associated with Severe COVID-19
Pinto, Bruna GG.
Oliveira, Antonio ER.
Singh, Youvika.
Jimenez, Leandro.
Goncalves, Andre NA.
Ogava, Rodrigo LT.
Creighton, Rachel.
Peron, Jean PS.
Nakaya, Helder I.
Acceso Abierto
Atribución-NoComercial-SinDerivadas
10.1101/2020.03.21.20040261
The pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in several thousand deaths worldwide in just a few months. Patients who died from Coronavirus disease 2019 (COVID-19) often had comorbidities, such as hypertension, diabetes, and chronic obstructive lung disease. The angiotensin-converting enzyme 2 (ACE2) was identified as a crucial factor that facilitates SARS-CoV2 to bind and enter host cells. To date, no study has assessed the ACE2 expression in the lungs of patients with these diseases. Here, we analyzed over 700 lung transcriptome samples of patients with comorbidities associated with severe COVID-19 and found that ACE2 was highly expressed in these patients, compared to control individuals. This finding suggests that patients with such comorbidities may have higher chances of developing severe COVID-19. We also found other genes, such as RAB1A, that can be important for SARS-CoV-2 infection in the lung. Correlation and network analyses revealed many potential regulators of ACE2 in the human lung, including genes related to histone modifications, such as HAT1, HDAC2, and KDM5B. In fact, epigenetic marks found in ACE2 locus were compatible to with those promoted by KDM5B. Our systems biology approach offers a possible explanation for increase of COVID-19 severity in patients with certain comorbidities.
www.medrxiv.org
2020
Artículo
https://www.medrxiv.org/content/10.1101/2020.03.21.20040261v1.full.pdf
Inglés
VIRUS RESPIRATORIOS
Aparece en las colecciones: Artículos científicos

Cargar archivos:


Fichero Tamaño Formato  
1108867.pdf1.79 MBAdobe PDFVisualizar/Abrir