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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/4980| A pneumonia outbreak associated with a new coronavirus of probable bat origin. | |
| Zhou Peng. Yang Xing-Lou. Wang Xian-Guang. Hu Ben. Zhang Lei. Zhang Wei. Si Hao-Rui. Zhu Yan. Li Bei. Huang Chao-Lin. Chen Hui-Dong. Chen Jing. Luo Yun. Guo Hua. Jiang Ren-Di. Liu Mei-Qin. Chen Ying. Shen Xu-Rui. Wang Xi. Zheng Xiao-Shuang. Zhao Kai. Chen Quan-Jiao. Deng Fei. Liu Lin-Lin. Yan Bing. Zhan Fa-Xian. Wang Yan-Yi. Xiao Geng-Fu. Shi Zheng-Li. | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1038/s41586-020-2012-7 | |
| Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1-4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5-7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor-angiotensin converting enzyme II (ACE2)-as SARS-CoV. | |
| Nature | |
| 2020 | |
| Artículo | |
| https://www.nature.com/articles/s41586-020-2012-7.pdf | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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