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Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19)
Alhazzani Waleed.
Møller Morten Hylander.
Arabi Yaseen M.
Loeb Mark.
Gong Michelle Ng.
Fan Eddy.
Oczkowski Simon.
Levy Mitchell M.
Derde Lennie.
Dzierba Amy.
Du Bin.
Aboodi Michael.
Wunsch Hannah.
Cecconi Maurizio.
Koh Younsuck.
Chertow Daniel S.
Maitland Kathryn.
Alshamsi Fayez.
Belley-Cote Emilie.
Greco Massimiliano.
Laundy Matthew.
Morgan Jill S.
Kesecioglu Jozef.
McGeer Allison.
Mermel Leonard.
Mammen Manoj J.
Alexander Paul E.
Arrington Amy.
Centofanti John E.
Citerio Giuseppe.
Baw Bandar.
Memish Ziad A.
Hammond Naomi.
Hayden Frederick G.
Evans Laura.
Rhodes Andrew.
Acceso Abierto
BACKGROUND:The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting thousands of people around the world. Urgent guidance for clinicians caring for the sickest of these patients is needed. METHODS:We formed a panel of 36 experts from 12 countries. All panel members completed the World Health Organization conflict of interest disclosure form. The panel proposed 53 questions that are relevant to the management of COVID-19 in the ICU. We searched the literature for direct and indirect evidence on the management of COVID-19 in critically ill patients in the ICU. We identified relevant and recent systematic reviews on most questions relating to supportive care. We assessed the certainty in the evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach, then generated recommendations based on the balance between benefit and harm, resource and cost implications, equity, and feasibility. Recommendations were either strong or weak, or in the form of best practice recommendations. RESULTS:The Surviving Sepsis Campaign COVID-19 panel issued 54 statements, of which 4 are best practice statements, 9 are strong recommendations, and 35 are weak recommendations. No recommendation was provided for 6 questions. The topics were: (1) infection control, (2) laboratory diagnosis and specimens, (3) hemodynamic support, (4) ventilatory support, and (5) COVID-19 therapy. CONCLUSION:The Surviving Sepsis Campaign COVID-19 panel issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19. When available, we will provide new recommendations in further releases of these guidelines.
Intensive Care Medicine
Appears in Collections:Artículos científicos

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