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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/4793| Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2 | |
| Youngchang Kim. Robert Jedrzejczak. Natalia I. Maltseva. Michael Endres. Adam Godzik. Karolina Michalska. Andrzej Joachimiak. | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1101/2020.03.02.968388 | |
| Severe Acute Respiratory Syndrome Coronavirus 2 is rapidly spreading around the world. There is no existing vaccine or proven drug to prevent infections and stop virus proliferation. Although this virus is similar to human and animal SARS- and MERS-CoVs the detailed information about SARS-CoV-2 proteins structures and functions is urgently needed to rapidly develop effective vaccines, antibodies and antivirals. We applied high-throughput protein production and structure determination pipeline at the Center for Structural Genomics of Infectious Diseases to produce SARS-CoV-2 proteins and structures. Here we report the high-resolution crystal structure of endoribonuclease Nsp15/NendoU from SARS-CoV-2 - a virus causing current world-wide epidemics. We compare this structure with previously reported models of Nsp15 from SARS and MERS coronaviruses. | |
| Protein science : a publication of the Protein Society | |
| 2020 | |
| Artículo | |
| https://www.biorxiv.org/content/10.1101/2020.03.02.968388v1.full.pdf | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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| 1107290.pdf | 6.55 MB | Adobe PDF | Visualizar/Abrir |