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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/464| Mendelian randomization of smoking behavior on cognitive status among older Americans | |
| Mingzhou Fu Yuan Jin Jessica D. Faul Kelly M Bakulski Erin Ware | |
| Novel Coronavirus | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1101/2019.12.11.19014522 | |
| Background: Smoking is a likely risk factor for dementia, and smoking behavior has a strong genetic component. In this study, we jointly test the associations between cumulative genetic risk for smoking, smoking behavior, and cognitive status using a Mendelian randomization framework. Methods: We conducted a cross-sectional study using the 2010 wave of the Health and Retirement Study database. Individuals aged between 50 and 90 were included. Smoking status was self-reported. Polygenic scores (PGSs) were calculated by weighting participant genotype by published smoking genome-wide association estimates. Cognitive status (normal, impaired, dementia) was measured using multiple assessments. A Mendelian randomization framework was used to infer causal relationships between smoking behavior and cognitive status via genetic instruments. Results: Among European ancestry participants (N = 8,735), current smoking behavior was positively associated with cognitive impairment (OR = 1.62, 95% CI: 1.29, 2.01) relative to normal cognition. Using smoking PGS as an instrumental variable, a causal relationship was observed between current smoking and cognitive impairment (OR = 1.53, 95% CI: 1.07, 2.18). There were no associations between smoking PGS, smoking behaviors and cognitive status in the African ancestry study sample (N = 2,511). Conclusions: Current smoking is a modifiable risk factor which causes cognitive impairment. Promotion of smoking cessation is important for public health. Further studies on dose and duration of smoking behaviors on cognitive impairment are critically needed, as well as in research other ancestries. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement All authors were supported by a grant from the National Institute on Aging (R01 AG055406). Dr. Bakulski was supported by grants from the National Institute for Environmental Health Sciences and National Institute for Minority Health and Health Disparities (R01 ES025531; R01 ES025574; OD023285; and R01 MD013299). Dr. Ware was supported by grants from the National Institute for Minority Health and Health Disparities (R01 MD012145) and the National Institute on Aging (R01 AG055654). This work was supported by the University of Michigan, Michigan Lifestage Environmental Exposures and Disease (M-LEEaD) National Institute for Environmental Health Sciences Core Center (P30 ES017885). ### Author Declarations All relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript. Yes All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes Data used in this manuscript are publicly available: https://hrs.isr.umich.edu/data-products Code used to produce analyses are publicly available: https://github.com/bakulskilab <https://hrs.isr.umich.edu/data-products> | |
| Cold Spring Harbor Laboratory Press | |
| 2019 | |
| Preimpreso | |
| https://www.medrxiv.org/content/10.1101/2019.12.11.19014522v1 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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