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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/4599| Serological immunochromatographic approach in diagnosis with SARS-CoV-2 infected COVID-19 patients | |
| Pan, Yunbao. Li, Xinran. Yang, Gui. Fan, Junli. Tang, Yueting. Zhao, Jin. Long, Xinghua. Guo, Shuang. Zhao, Ziwu. Liu, Yinjuan. Hu, Hanning. Xue, Han. Li, Yirong. | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1101/2020.03.13.20035428 | |
| An outbreak of new coronavirus SARS-CoV-2 was occurred in Wuhan, China and rapidly spread to other cities and nations. The standard diagnostic approach that widely adopted in the clinic is nuclear acid detection by real-time RT-PCR. However, the false-negative rate of the technique is unneglectable and serological methods are urgently warranted. Here, we presented the colloidal gold-based immunochromatographic (ICG) strip targeting viral IgM or IgG antibody and compared it with real-time RT-PCR. The sensitivity of ICG assay with IgM and IgG combinatorial detection in nuclear acid confirmed cases were 11.1%, 92.9% and 96.8% at the early stage (1-7 days after onset), intermediate stage (8-14 days after onset), and late-stage (more than 15 days), respectively. The ICG detection capacity in nuclear acid-negative suspected cases was 43.6%. In addition, the consistencies of whole blood samples with plasma were 100% and 97.1% in IgM and IgG strips, respectively. In conclusion, serological ICG strip assay in detecting SARS-CoV-2 infection is both sensitive and consistent, which is considered as an excellent supplementary approach in clinical application. | |
| Journal of Infection | |
| 2020 | |
| Artículo | |
| https://www.medrxiv.org/content/10.1101/2020.03.13.20035428v1.full.pdf | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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