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Regaining perspective on SARS-CoV-2 molecular tracing and its implications
Carla Mavian.
Simone Marini.
Costanza Manes.
Ilaria Capua.
Mattia Prosperi.
Marco Salemi.
Acceso Abierto
Atribución-NoComercial-SinDerivadas
10.1101/2020.03.16.20034470
During the past three months, a new coronavirus (SARS-CoV-2) epidemic has been growing exponentially, affecting over 100 thousand people worldwide, and causing enormous distress to economies and societies of affected countries. A plethora of analyses based on viral sequences has already been published, in scientific journals as well as through non-peer reviewed channels, to investigate SARS-CoV-2 genetic heterogeneity and spatiotemporal dissemination. We examined all full genome sequences currently available to assess the presence of sufficient information for reliable phylogenetic and phylogeographic studies. Our analysis clearly shows severe limitations in the present data, in light of which any finding should be considered, at the very best, preliminary and hypothesis-generating. Hence the need for avoiding stigmatization based on partial information, and for continuing concerted efforts to increase number and quality of the sequences required for robust tracing of the epidemic.
www.medrxiv.org
2020
Artículo
https://www.medrxiv.org/content/10.1101/2020.03.16.20034470v1.full.pdf
Inglés
VIRUS RESPIRATORIOS
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