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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/442| Erosion of representativeness in a cohort study | |
| Julia A Brettschneider David Steinsaltz Maria D Christodoulou | |
| Novel Coronavirus | |
| Acceso Abierto | |
| Atribución-SinDerivadas | |
| 10.1101/2020.02.13.20022012 | |
| Background: The National Child and Development Study (1958 British Birth Cohort) follows the lives of over 17 000 people born in a single week in England, Scotland, and Wales. After initial recruitment, there have been nine sweeps to gather subsequent life-course data and a Biomedical Sweep (between Sweeps 6 and 7) that has been used in genetic studies. Due to its non-selective recruitment, the survey is frequently used as a representative proxy for the British population in demographic, epidemiological, and medical studies. We examine the effect of attrition on representativeness of female fertility and education length. Methods: We compare numbers and timings of fertility-related events of female cohort members with national estimates. Spline approximation was used to link records with different aggregation intervals. Participants who were present in the Biomedical Sweep were compared to those who were not. Results: We established that both timings and counts of maternities and terminations in the cohort diverge from the patterns of their contemporaries. For women who participated in the Biomedical Sweep, we noted positive correlations of study continuation with years spent in full time education, and with age at first birth. We determined that women who did not participate in the Biomedical Sweep reported different fertility patterns from those who did. Conclusions: For female fertility, the 1958 Birth Cohort is an imperfect proxy for the British population, making the description "broadly representative" potentially misleading. Worsening bias due to attrition and misreporting can be identified and quantified through comparisons with national vital statistics. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This work was supported by the Biotechnology and Biological Sciences Research Council [BB/S001824/1] ### Author Declarations All relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript. Yes All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes Data governance was provided by the METADAC data access committee, funded by ESRC, Wellcome, and MRC. (Grant Number: MR/N01104X/1) This work made use of data and samples generated by the 1958 Birth Cohort (NCDS), which is managed by the Centre for Longitudinal Studies at the UCL Institute of Education, funded by the Economic and Social Research Council (grant number ES/M001660/1). Access to these resources was enabled via the Wellcome Trust & MRC: 58FORWARDS grant [108439/Z/15/Z] (The 1958 Birth Cohort: Fostering new Opportunities for Research via Wider Access to Reliable Data and Samples). Before 2015 biomedical resources were maintained under the Wellcome Trust and Medical Research Council 58READIE Project (grant numbers WT095219MA and G1001799). | |
| Cold Spring Harbor Laboratory Press | |
| 2020 | |
| Preimpreso | |
| https://www.medrxiv.org/content/10.1101/2020.02.13.20022012v1 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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