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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/4399| In Silico Investigations on the Potential Inhibitors for COVID-19 Protease | |
| Ambrish Kumar Srivastava. Abhishek Kumar. Gargi Tiwari. Ratnesh Kumar. Neeraj Misra. | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://arxiv.org/pdf/2003.10642v2.pdf | |
| A novel strain of coronavirus, namely, COVID-19 has been identified in Wuhan city of China in December 2019. There are no specific therapies available and investigations regarding the treatment of the COVID-19 are still lacking. This prompted us to perform a preliminary in silico study on the COVID-19 protease with anti-malarial compounds in the search of potential inhibitor. We have calculated log P and log S values in addition to molecular docking and PASS predictions. Among the seven studied compounds, mepacrine appears as the potential inhibitor of the COVID-19 followed by chloroquine, hydroxychloroquine and phomarin. Therefore, these anti-malarial drugs may be potential drug candidate for the treatment of this novel coronavirus. A detailed analysis on these inhibitors is currently in progress and clinical studies are invited to investigate their potential medicinal use for the COVID-19. | |
| arxiv.org | |
| 2020 | |
| Artículo | |
| https://arxiv.org/pdf/2003.10642v2.pdf | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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