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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/438| The Epidemiology of Plasmodium vivax Among Adults in the Democratic Republic of the Congo: A Nationally-Representative, Cross-Sectional Survey | |
| Molly Deutsch-Feldman Oliver J. Watson Kyaw L. Thwai Andreea Waltmann Michael Emch Valerie Gartner Cedar L. Mitchell Steven R. Meshnick Benjamin Redelings Gregory Wray Melchior K. Mwandagalirwa Antoinette K. Tshefu Joris L. Likwela Jess K. Edwards Robert Verity Jonathan B. Parr Jonathan J. Juliano Andrew P. Morgan Nicholas F. Brazeau | |
| Novel Coronavirus | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1101/2020.02.17.20024190 | |
| Background Reports of P. vivax infections among Duffy-negative hosts have begun to accumulate throughout sub-Saharan Africa. Despite this growing body of evidence, no nationally representative epidemiological surveys of P. vivax in sub-Saharan Africa nor population genetic analyses to determine the source of these infections have been performed. Methods To overcome this critical gap in knowledge, we screened nearly 18,000 adults in the Democratic Republic of the Congo (DRC) for P. vivax using samples from the 2013-2014 Demographic Health Survey. Infections were identified by quantitative PCR and confirmed with nested-PCR. P. vivax mitochondrial genomes were constructed after short-read sequencing. Risk factors, spatial distributions and population genetic analyses were explored. Findings Overall, we found a 2.96% (95% CI: 2.28%, 3.65%) prevalence of P. vivax infections across the DRC. Nearly all infections were among Duffy negative adults (486/489). Infections were not associated with typical malaria risk-factors and demonstrated small-scale heterogeneity in prevalence across space. Mitochondrial genomes suggested that DRC P. vivax is an older clade that shares its most recent common ancestor with South American isolates. Interpretation P. vivax is more prevalent across the DRC than previously believed despite widespread Duffy-negativity. Comparison to global and historical P. vivax sequences suggests that historic DRC P. vivax may have been transported to the New World on the wave of European expansion. Our findings suggest congolese P. vivax is an innocuous threat given its relatively flat distribution across space, lack of malaria risk factors, and potentially ancestral lineage. ### Competing Interest Statement JBP reports support from the World Health Organization; JPB and SRM report non-financial support from Abbott Laboratories, which has performed laboratory testing in-kind as part of their hepatitis research, outside of the submitted work. ### Funding Statement This research was funded by the National Institutes of Health: F30AI143172 (NFB), R01TW010870 (JJJ), K24AI13499 (JJJ), R01AI107949 (SRM), F30MH103925 (APM), T32AI070114 (MDF) and the Wellcome Trust: 109312/Z/15/Z (OJW). ### Author Declarations All relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript. Yes All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes Pending | |
| Cold Spring Harbor Laboratory Press | |
| 2020 | |
| Preimpreso | |
| https://www.medrxiv.org/content/10.1101/2020.02.17.20024190v1 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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| The Epidemiology of Plasmodium.pdf | 1.36 MB | Adobe PDF | Visualizar/Abrir |