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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/431| Association of social isolation, loneliness, and genetic risk with incidence of dementia: UK Biobank cohort study | |
| Anni Malmberg Marianna Virtanen Christian Hakulinen Marko Elovainio Matti Pirinen Jari Lahti Mika Kivimaki Jari Lipsanen Laura Pulkki-Raback | |
| Novel Coronavirus | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1101/2020.02.25.20027177 | |
| Objective: To examine the associations of social isolation and loneliness with incident dementia by level of genetic risk. Design: Prospective population-based cohort study. Setting and participants: 155 074 men and women (mean age 64.1, SD 2.9 years) from the UK Biobank Study, recruited between 2006 and 2010. Main exposures: Self-reported social isolation and loneliness, and polygenic risk score for Alzheimers disease with low (lowest quintile), intermediate (quintiles 2 to 4), and high (highest quintile) risk categories. Main outcome: Incident all-cause dementia ascertained using electronic health records. Results: Overall, 8.6% of participants reported that they were socially isolated and 5.5% were lonely. During a mean follow-up of 8.8 years (1.36 million person-years), 1444 (0.9% of the total sample) were diagnosed with dementia. Social isolation, but not loneliness, was associated with increased risk of dementia (hazard ratio 1.62, 95% confidence interval 1.38 to 1.90). Of the participants who were socially isolated and had high genetic risk, 4.2% (2.9% to 5.5%) were estimated to develop dementia compared with 3.1% (2.7% to 3.5%) in participants who were not socially isolated but had high genetic risk. The corresponding estimated incidence in the socially isolated and not isolated were 3.9% (3.1% to 4.6%) and 2.5% (2.2% to 2.6%) in participants with intermediate genetic risk. Conclusion: Socially isolated individuals are at increased risk of dementia at all levels of genetic risk. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement ME and CH were supported by the Academy of Finland (329224 (ME) / 310591(CH)). MK was supported by NordForsk (70521), the UK Medical Research Council (MRC S011676), the Academy of Finland (311492), and the US National Institutes on Ageing (NIA R01AG056477). The funding sources did not participate in the design or conduct of the study; collection, management, analysis or interpretation of the data; or preparation, review, or approval of the manuscript. ### Author Declarations All relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript. Yes All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes The genetic and phenotypic UK Biobank data are available on application to the UK Biobank (www.ukbiobank.ac.uk/). Present study was conducted using the UK Biobank Resource under Application 14801. Summary statistics from the meta-analysis of genome wide association studies in dementia are available from https://www.niagads.org/datasets/ng00075 <htto://www.ukbiobank.ac.uk> | |
| Cold Spring Harbor Laboratory Press | |
| 2020 | |
| Preimpreso | |
| https://www.medrxiv.org/content/10.1101/2020.02.25.20027177v1 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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