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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/4292| Topoisomerase III-beta is required for efficient replication of positive-sense RNA viruses | |
| K. Reddisiva Prasanth. Minato Hirano. W. Samuel Fagg. Eileen McAnarney. Shao Chan. Xuping Xie. Adam Hage. Colette Pietzsch. Alexander Bukreyev. Ricardo Rajsbaum. Pei-Yong Shi. Mark Bedford. Shelton Bradrick. Vineet D Menachery. Mariano A Garcia-Blanco. | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1101/2020.03.24.005900 | |
| Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-{beta} (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded RNA viruses tested, including SARS-CoV-2. While there are no drugs that specifically inhibit this topoisomerase, we posit that TOP3B is an attractive anti-viral target. | |
| www.biorxiv.org | |
| 2020 | |
| Artículo | |
| https://www.biorxiv.org/content/10.1101/2020.03.24.005900v1.full.pdf | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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| 1106252.pdf | 1.33 MB | Adobe PDF | Visualizar/Abrir |