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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/4280| Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility. | |
| HL Ji. R Zhao. S Matalon. MA Matthay. | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1152/physrev.00013.2020 | |
| Patients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, chronic obstructive pulmonary disease, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. The purpose of this review is to summarize the evidence for the existence of elevated plasmin(ogen) in COVID-19 patients with these comorbid conditions. Plasmin, and other proteases, may cleave a newly inserted furin site in the S protein of SARS-CoV-2, extracellularly, which increases its infectivity and virulence. Hyperfibrinolysis associated with plasmin leads to elevated D-dimer in severe patients. The plasmin(ogen) system may prove a promising therapeutic target for combating COVID-19. | |
| Physiological reviews | |
| 2020 | |
| Artículo | |
| https://journals.physiology.org/doi/pdf/10.1152/physrev.00013.2020 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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|---|---|---|---|
| 1106232.pdf | 1.26 MB | Adobe PDF | Visualizar/Abrir |