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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/4273| Electrical probing of COVID-19 spike protein receptor binding domain via a graphene field-effect transistor | |
| Xiaoyan Zhang. Qige Qi. Qiushi Jing. Shen Ao. Zhihong Zhang. Mingchao Ding. Muhong Wu. Kaihui Liu. Weipeng Wang. Yunhan Ling. Zhengjun Zhang. Wangyang Fu. | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://arxiv.org/pdf/2003.12529v1.pdf | |
| Here, in an effort towards facile and fast screening/diagnosis of novel coronavirus disease 2019 (COVID-19), we combined the unprecedently sensitive graphene field-effect transistor (Gr-FET) with highly selective antibody-antigen interaction to develop a coronavirus immunosensor. The Gr-FET immunosensors can rapidly identify (about 2 mins) and accurately capture the COVID-19 spike protein S1 (which contains a receptor binding domain, RBD) at a limit of detection down to 0.2 pM, in a real-time and label-free manner. Further results ensure that the Gr-FET immunosensors can be promisingly applied to screen for high-affinity antibodies (with binding constant up to 2*10^11 M^-1 against the RBD) at concentrations down to 0.1 pM. Thus, our developed electrical Gr-FET immunosensors provide an appealing alternative to address the early screening/diagnosis as well as the analysis and rational design of neutralizing-antibody locking methods of this ongoing public health crisis. | |
| arxiv.org | |
| 2020 | |
| Artículo | |
| https://arxiv.org/pdf/2003.12529v1.pdf | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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