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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/4153| A Multi-hospital Study in Wuhan, China:Protective Effects of Non-menopause and Female Hormones on SARS-CoV-2 infection | |
| Ting Ding. Jinjin Zhang. Tian Wang. Pengfei Cui. Zhe Chen. Jingjing Jiang. Su Zhou. Jun Dai. Bo Wang. Suzhen Yuan. Wenqing Ma. Lingwei Ma. Yueguang Rong. Jiang Chang. Xiaoping Miao. Xiangyi Ma. Shixuan Wang. | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1101/2020.03.26.20043943 | |
| Objective To determine the correlation between menstruation status/sex hormones and prognosis of COVID-19, and to identify potential protective factors for female patients. Design, Setting, and Participants A cross-sectional study of COVID-19 patients who were hospitalized at Tongji and Mobile Cabin Hospitals from Jan 28, 2020 to March 8, 2020. Sex differences in severity and composite endpoints (admission to intensive care unit (ICU), use of mechanical ventilation, or death) of COVID-19 patients were compared. The correlation analysis and cox/logistic regression modeling of menstruation status/sex hormones and prognosis were conducted. Correlation between cytokines related to immunity and inflammation and disease severity or estradiol (E2) was revealed.Results Chi square test indicated significant differences in distribution of composite endpoints (p<0.01) and disease severity (p=0.05) between male and female patients (n=1902). 435 female COVID-19 patients with menstruation records were recruited. By the end of Mar 8, 111 patients recovered and discharged (25.3%). Multivariate Cox regression model adjusted for age and severity indicated that post-menopausal patients show the greater risk of hospitalization time than non-menopausal patients (relative hazard [RH], 1.91; 95% confidence interval [CI], 1.06-3.46)Logistic regression model showed that higher AMH as a control for age increases the risk of severity of COVID-19 (HR=0.146, 95%CI= (0.026-0.824) p=0.029). E2 showed protective effect against disease severity (HR=0.335, 95%CI= (0.105-1.070), p=0.046).In the Mann-Whitney U test, the higher levels of IL6 and IL8 were found in severe group (p=0.040, 0.033).The higher levels of IL2R, IL6, IL8 and IL10 were also observed in patients with composite end points(p<0.001,<0.001, =0.009, = 0.040).E2 levels were negatively correlated with IL2R, IL6, IL8 and TNF in luteal phase (Pearson Correlation=-0.592, -0.558, -0.545, -0.623; p=0.033, 0.048, 0.054, 0.023) and with C3 in follicular phase (Pearson Correlation=-0.651; p=0.030). Conclusions and Relevance Menopause is an independent risk factor for COVID-19. E2 and AMH are negatively correlated with COVID-19 severity probably due to their regulation of cytokines related to immunity and inflammation. | |
| www.medrxiv.org | |
| 2020 | |
| Artículo | |
| https://www.medrxiv.org/content/10.1101/2020.03.26.20043943v1.full.pdf | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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