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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/415| The role of the metabolic profile in mediating the relationship between body mass index and left ventricular mass in adolescents: analysis of a prospective cohort study | |
| Amy E Taylor Deborah A Lawlor George Davey Smith Naveed Sattar Nishi Chaturvedi Alun D Hughes Laura D Howe Diana Dos Santos Ferreira Alice R Carter | |
| Novel Coronavirus | |
| Acceso Abierto | |
| Atribución | |
| 10.1101/2020.03.09.20033324 | |
| Background: We aimed to quantify the role of the plasma metabolic profile in explaining the effect of adiposity on cardiac structure. Methods: Body mass index (BMI) was measured at age 11 in the Avon Longitudinal Study of Parents and Children. Left ventricular mass indexed to height2.7 (LVMI), was assessed by echocardiography at age 17. The metabolic profile was quantified via nuclear magnetic resonance spectroscopy at age 15. Multivariable confounder (maternal age, parity, highest qualification, maternal smoking, pre-pregnancy BMI, pre-pregnancy height, household social class and adolescent birthweight, adolescent smoking, fruit and vegetable consumption, physical activity) -adjusted linear regression estimated the association of BMI with LVMI and mediation by metabolic traits. We considered 156 metabolomic traits individually, jointly as principal components (PCs) explaining 95% of the variance in the NMR platform, and assessed whether the PCs for the metabolic traits added to the proportion of the association explained by established cardiovascular risk factors (systolic and diastolic blood pressure, insulin, triglycerides, low density lipoprotein, and glucose). Results: A 1kg/m2 higher BMI was associated with a 0.70 g/m2.7 (0.53, 0.88) and 0.66 g/m2.7 (0.53, 0.79) higher LVMI in males (N=437) and females (N=536), respectively. Established risk factors explained 3% (95% CI: 2% to 5%) of this association in males, increasing to 10% (95% CI: 8%, 13%) when including metabolic PCs. In females, the standard risk factors explained 3% (95% CI: 2%, 5%) of the association, and did not increase when including the metabolic PCs. Conclusion: The addition of the NMR measured metabolic traits appear to mediate more of the effect of BMI on LVMI than the established risk factors alone in adolescent males, but not females. ### Competing Interest Statement DAL has received support from several national and international government and charitable funders, as well as Medtronic Ltd and Roche Diagnostics in the last 10-years, for work unrelated to that presented here. All other authors have no conflicts of interest to declare ### Funding Statement ARC, DLSF, AET, DAL, GDS and LDH all work in a unit supported by the UK Medical Research Council and the University of Bristol (Program codes: MC_UU_00011/1 and MC_UU_00011/6]. ARC is supported by a UK Medical Research Council PhD Studentship (MC_UU_00011/1). DAL, AET and GDS are supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at University Hospitals Bristol NHS Foundation and the University of Bristol. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health. DALs contribution is supported by the European Unions Horizon 2020 research and innovation programme under grant agreement No 733206 (LifeCycle). The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. NMR metabolomics data was funded by the MRC (Grant ref: MC_UU_12013/1) AH received support from the Wellcome Trust (086676/7/08/Z) and the British Heart Foundation (PG/06/145 & CS/15/6/31468) for cardiovascular measures in ALSPAC and works in a unit that receives support from the UK Medical Research Council (Program code: MC_UU_12019/1). LDH is supported by a Career Development Award fellowship from the UK Medical Research Council (MR/M020894/1). No funding body has influenced data collection, analysis or its interpretations. This publication is the work of the authors, who serve as the guarantors for the contents of this paper. ### Author Declarations All relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript. Yes All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes Code is available from the corresponding author. | |
| Cold Spring Harbor Laboratory Press | |
| 2020 | |
| Preimpreso | |
| https://www.medrxiv.org/content/10.1101/2020.03.09.20033324v1 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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