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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/412| Integrating epidemiological and genetic data with different sampling intensities into a dynamic model of respiratory syncytial virus (RSV) transmission. | |
| Charles N Agoti Patrick K Munywoki D James Nokes Graham F Medley Ivy Kadzo Kombe | |
| Novel Coronavirus | |
| Acceso Abierto | |
| Atribución | |
| 10.1101/2020.03.08.20030742 | |
| Background: Respiratory syncytial virus (RSV) is responsible for a significant burden of acute respiratory illness in children under 5 years old. Prior to rolling out any vaccination program, identification of the source of infant infections could further guide vaccination strategies. Methods: We extended a dynamic model calibrated at the individual host level initially fit to social-temporal data on shedding patterns to include whole genome sequencing data available at a lower sampling intensity. Results: In this study population of 493 individuals with 55 infants under the age of 1 year distributed across 47 households, we found that 52% of RSV-B and 60% of RSV-A cases arose from infection within the household. Forty-five percent of infant infections appeared to occur in the household, of which 68% were a result of transmission from a child aged between 2 and 13 years living in the same household as the infant. Conclusion: These results further highlight the importance of pre-school and school-aged children in RSV transmission, particularly the role they play in directly infecting the household infant. These age groups are a potential RSV vaccination target group. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This work was supported through the DELTAS Africa Initiative [DEL-15-003]. The DELTAS Africa Initiative is an independent funding scheme of the African Academy of Sciences (AAS)s Alliance for Accelerating Excellence in Science in Africa (AESA) and supported by the New Partnership for Africas Development Planning and Coordinating Agency (NEPAD Agency) with funding from the Wellcome Trust [107769/Z/10/Z, 102975 and 090853] and the UK government. The views expressed in this publication are those of the authors and not necessarily those of AAS, NEPAD Agency, Wellcome Trust or the UK government. ### Author Declarations All relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript. Yes All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes The data used to generate the social-temporal shedding patterns is available under the Creative Commons Attribution 4.0 International (CC BY 4.0). For access to data and more detailed information beyond the metadata provided, there is a process of managed access requiring submission of a request form for consideration by the Data Governance Committee at KEMRI-Wellcome Trust Research Programme (http://kemri-wellcome.org/about-us/#ChildVerticalTab_15). The sequence data used in this study can be found in both GenBank and Short Read Archive databases (see accession details in the Supplementary Dataset for the original manuscript https://www.nature.com/articles/s41598-019-46509-w). <http://kemri-wellcome.org/about-us/#ChildVerticalTab_15> <https://www.nature.com/articles/s41598-019-46509-w> | |
| Cold Spring Harbor Laboratory Press | |
| 2020 | |
| Preimpreso | |
| https://www.medrxiv.org/content/10.1101/2020.03.08.20030742v1 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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