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COVID-19 for the Cardiologist: A Current Review of the Virology, Clinical Epidemiology, Cardiac and Other Clinical Manifestations and Potential Therapeutic Strategies
Atri Deepak.
Siddiqi Hasan K.
Lang Joshua.
Nauffal Victor.
Morrow David A.
Bohula Erin A.
Acceso Abierto
Atribución-NoComercial-SinDerivadas
10.1016/j.jacbts.2020.04.002
The coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), has reached pandemic status. As it spreads across the world, it has overwhelmed healthcare systems, strangled the global economy and led to a devastating loss of life. Widespread efforts from regulators, clinicians and scientists are driving a rapid expansion of knowledge of the SARS-CoV2 virus and the COVID-19 disease. We review the most current data with a focus on our basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. We discuss the basic virology, epidemiology, clinical manifestation, multi-organ consequences, and outcomes. With a focus on cardiovascular complications, we propose several mechanisms of injury. The virology and potential mechanism of injury form the basis for a discussion of potential disease-modifying therapies.
JACC: Basic to Translational Science
2020
Artículo
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151394/pdf/main.pdf
Inglés
VIRUS RESPIRATORIOS
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