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Distinct early IgA profile may determine severity of COVID-19 symptoms: an immunological case series
Christine Dahlke.
Jasmin Heidepriem.
Robin Kobbe.
Rene Santer.
Till Koch.
Anahita Fathi.
My L Ly.
Stefan Schmiedel.
Peter H Seeberger.
ID-UKE COVID-19 study group.
Marylyn M Addo.
Felix F Loeffler.
Acceso Abierto
Atribución-NoComercial-SinDerivadas
10.1101/2020.04.14.20059733
SARS-CoV-2 is the causative agent of COVID-19 and is a severe threat to global health. Patients infected with SARS-CoV-2 show a wide range of symptoms and disease severity, while limited data is available on its immunogenicity. Here, the kinetics of the development of SARS-CoV-2-specific antibody responses in relation to clinical features and dynamics of specific B-cell populations are reported. Immunophenotyping of B cells was performed by flow cytometry with longitudinally collected PBMCs. In parallel, serum samples were analyzed for the presence of SARS-CoV-2-specific IgA, IgG, and IgM antibodies using whole proteome peptide microarrays. Soon after disease onset in a mild case, we observed an increased frequency of plasmablasts concomitantly with a strong SARS-CoV-2-specific IgA response. In contrast, a case with more severe progression showed a delayed, but eventually very strong and broad SARS-CoV-2-specific IgA response. This case study shows that determining SARS-CoV-2-specific antibody epitopes can be valuable to monitor the specificity and magnitude of the early B-cell response, which could guide the development of vaccine candidates. Follow-up studies are required to evaluate whether the kinetics and strength of the SARS-CoV-2-specific IgA response could be potential prognostic markers of viral control.
www.medrxiv.org
2020
Artículo
https://www.medrxiv.org/content/10.1101/2020.04.14.20059733v1.full.pdf
Inglés
VIRUS RESPIRATORIOS
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