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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/346| Association between CCR5-Δ32 homozygosity and mortality in 37,650 participants from three U.S.-based cohorts | |
| Francine Grodstein Hongyan Huang Xia Jiang Peter Kraft | |
| Novel Coronavirus | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1101/19006619 | |
| An analysis of 409,693 UK Biobank participants recently published in Nature Medicine identified a relative 21% increase in all-cause mortality among participants who were homozygous for the Δ32 deletion in the C-C motif chemokine receptor 5 gene (CCR5). This is a timely and potentially cautionary result in light of He Jiankui's controversial germline editing of CCR5 to induce mutations that putatively mimic the effects of Δ32, which is known to reduce the risk of HIV infection. To provide additional evidence on the association between the Δ32 deletion and mortality and assess its generalizability, we present results from three large-scale population-based US cohorts: the Nurses' Health Study (NHS), the NHSII and the Health Professional Follow-Up Study (HPFS). ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This work was supported by U.S. National Institutes of Health Grants U01 CA186107, R01 CA49449, U01 CA176726, R01 CA67262, and U01 CA167552. Dr. Jiang is supported by the International Postdoc Grant from the Swedish Research Council ### Author Declarations All relevant ethical guidelines have been followed and any necessary IRB and/or ethics committee approvals have been obtained. Yes All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes Any clinical trials involved have been registered with an ICMJE-approved registry such as ClinicalTrials.gov and the trial ID is included in the manuscript. Not Applicable I have followed all appropriate research reporting guidelines and uploaded the relevant Equator, ICMJE or other checklist(s) as supplementary files, if applicable. Yes Data are available upon request, see: https://www.nurseshealthstudy.org/researchers and https://sites.sph.harvard.edu/hpfs/for-collaborators/. | |
| Cold Spring Harbor Laboratory Press | |
| 2019 | |
| Preimpreso | |
| https://www.medrxiv.org/content/10.1101/19006619v1 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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| Association between CCR5.pdf | 64.71 kB | Adobe PDF | Visualizar/Abrir |