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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/335| Genetic risk of obesity as a modifier of associations between neighbourhood environment and body mass index: an observational study of 335,046 UK Biobank participants | |
| Steven Cummins Jody Phelan Neil Pearce Luigi Palla Kate E Mason | |
| Novel Coronavirus | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1101/19004671 | |
| Background: There is growing recognition that recent global increases in obesity are the product of a complex interplay between genetic and environmental factors. However, in gene-environment studies of obesity, "environment" usually refers to individual behavioural factors that influence energy balance, while more upstream environmental factors are overlooked. We examined gene-environment interactions between genetic risk of obesity and two neighbourhood characteristics likely to be associated with obesity (proximity to takeaway/fast-food outlets and availability of physical activity facilities). Methods: We used data from 335,046 adults aged 40-70 in the UK Biobank cohort to conduct a population-based cross-sectional study of interactions between neighbourhood characteristics and genetic risk of obesity, in relation to BMI. Proximity to a fast-food outlet was defined as distance from home address to nearest takeaway/fast-food outlet, and availability of physical activity facilities as the number of formal physical activity facilities within one kilometre of home address. Genetic risk of obesity was operationalised by 91-SNP and 69-SNP weighted genetic risk scores, and by six individual SNPs considered separately. Multivariable, mixed effects models with product terms for the gene-environment interactions were estimated. Results: After accounting for likely confounding, the association between proximity to takeaway/fast-food outlets and BMI was stronger among those at increased genetic risk of obesity, with evidence of an interaction with polygenic risk scores (P=0.018 and P=0.028 for 69-SNP and 91-SNP scores, respectively) and in particular with a SNP linked to MC4R (P=0.009), a gene known to regulate food intake. We found very little evidence of a gene-environment interaction for availability of physical activity facilities. Conclusions: Individuals at an increased genetic risk of obesity may be more sensitive to exposure to the local fast-food environment. Ensuring that neighbourhood residential environments are designed to promote a healthy weight may be particularly important for those with greater genetic susceptibility to obesity ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement KM was funded by a Commonwealth Scholarship Commission PhD Scholarship. NP was supported by the Wellcome Trust Institutional Strategic Support Fund, 097834/Z/11/B through the Centre for Global NCDs and SC is supported by Health Data Research UK. Our funders had no role in any stage of this study, nor in the preparation of the manuscript for publication. ### Author Declarations All relevant ethical guidelines have been followed and any necessary IRB and/or ethics committee approvals have been obtained. Yes All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes Any clinical trials involved have been registered with an ICMJE-approved registry such as ClinicalTrials.gov and the trial ID is included in the manuscript. Not Applicable I have followed all appropriate research reporting guidelines and uploaded the relevant Equator, ICMJE or other checklist(s) as supplementary files, if applicable. Yes Data are available from UK Biobank to approved researchers <https://www.ukbiobank.ac.uk/> | |
| Cold Spring Harbor Laboratory Press | |
| 2019 | |
| Preimpreso | |
| https://www.medrxiv.org/content/10.1101/19004671v2 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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