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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/3164| ACE2 variants underlie interindividual variability and susceptibility to COVID-19 in Italian population | |
| Renieri Alessandra. Benetti Elisa. Tita Rossella. Spiga Ottavia. Ciolfi Andrea. Birolo Giovanni. Bruselles Alessandro. Doddato Gabriella. Giliberti Annarita. Marconi Cterina. Musacchia Francesco. Pippucci Tommaso. Torella Annalaura. Trezza Alfonso. Valentino Floriana. Baldassarri Mrgherita. Brusco Alfredo. Asselta Rosanna. Mirella Bruttini. Furini Simone. Seri Marco. Nigro Vincenzo. Matullo Giuseppe. Tartaglia Marco. Mari Francesca. Pinto Annamaria. | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1101/2020.04.03.20047977 | |
| In December 2019, an initial cluster of unexpected interstitial bilateral pneumonia emerged in Wuhan, Hubei province. A human-to-human transmission was immediately assumed and a previously unrecognized entity, termed coronavirus disease 19 (COVID-19) due to a novel coronavirus (2019-nCov) was suddenly described. The infection has rapidly spread out all over the world and Italy has been the first European Country experiencing the endemic wave with unexpected clinical severity in comparison with Asian countries. It has recently been shown that 2019-nCov utilizes host receptors namely angiotensin converting enzyme 2 (ACE2) as host receptor and host proteases for cell surface binding and internalization. Thus, a predisposing genetic background can give reason for interindividual disease susceptibility and/or severity. Taking advantage of the Network of Italian Genomes (NIG), here we mined around 7000 exomes from 5 different Centers looking for ACE2 variants. A number of variants with a potential impact on protein stability were identified. Among these, three missense changes, p.Asn720Asp, p.Lys26Arg, p.Gly211Arg (MAF 0.002 to 0.015), which have never been reported in the Eastern Asia population, were predicted to interfere with protein cleavage and stabilization. Rare truncating variants likely interfering with the internalization process and one missense variant, p.Trp69Cys, predicted to interfere with 2019-nCov spike protein binding were also observed. These findings suggest that a predisposing genetic background may contribute to the observed inter-individual clinical variability associated with COVID-19. They allow an evidence-based risk assessment opening up the way to personalized preventive measures and therapeutic options. | |
| www.medrxiv.org | |
| 2020 | |
| Artículo | |
| https://www.medrxiv.org/content/medrxiv/early/2020/04/06/2020.04.03.20047977.full.pdf | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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| 1103568.pdf | 1.06 MB | Adobe PDF | Visualizar/Abrir |