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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/314| Whole genome sequencing detects minimal clustering among Escherichia coli Sequence Type 131 H30 isolates collected from U.S. children's hospitals | |
| Danielle M. Zerr Janet G. Baseman Amanda A. Adler Scott J. Weissmann Arianna Miles-Jay | |
| Novel Coronavirus | |
| Acceso Abierto | |
| Atribución | |
| 10.1101/19010140 | |
| Escherichia coli sequence type 131 H30 has garnered global attention as a dominant antimicrobial-resistant lineage of extraintestinal pathogenic E. coli , but its transmission dynamics remain undefined. We applied whole genome sequencing to identify putative transmission clusters among clinical isolates of H30 from children across the U.S. Of 126 isolates, 17 were involved in 8 putative transmission clusters; 4 clusters involved isolates with some evidence of healthcare-associated epidemiologic linkages. Geographic clustering analyses showed weak geographic clustering. These findings are consistent with a framework where within-hospital transmission is not a main contributor to the propagation of H30 in a pediatric setting. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This work was supported by Seattle Childrens Research Institutes Center for Clinical and Translational Research Pediatric Pilot Fund program; and the National Institutes of Health via the National Institute of Allergy and Infectious Diseases (grant number R01AI083413), and the National Center for Advancing Translational Sciences (grant number TL1TR000422). The authors or their institutions have not received payment or services for any aspect of the submitted work. ### Author Declarations All relevant ethical guidelines have been followed and any necessary IRB and/or ethics committee approvals have been obtained. Yes All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes Any clinical trials involved have been registered with an ICMJE-approved registry such as ClinicalTrials.gov and the trial ID is included in the manuscript. Not Applicable I have followed all appropriate research reporting guidelines and uploaded the relevant Equator, ICMJE or other checklist(s) as supplementary files, if applicable. Not Applicable Sequence data generated are available from the NCBI Sequence Read Archive under BioProject PRJNA578285 | |
| Cold Spring Harbor Laboratory Press | |
| 2019 | |
| Preimpreso | |
| https://www.medrxiv.org/content/10.1101/19010140v1 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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