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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/311| Per- and poly-fluoroalkyl substances and bone mineral density: results from the Bayesian weighted quantile sum regression | |
| Chris Gennings Stefanie Busgang Nicolo Foppa Pedretti Elena Colicino | |
| Novel Coronavirus | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1101/19010710 | |
| Background: Per- and poly-fluoroalkyl substances (PFAS) are chemicals, detected in 95% of Americans, that induce osteotoxicity and modulate hormones thereby influencing bone health. Previous studies found associations between individual PFAS and bone mineral density but did not analyze their combined effects. Objective: To extend weighted quantile sum (WQS) regression to a Bayesian framework (BWQS) and determine the association between a mixture of serum PFAS and mineral density in lumbar spine, total and neck femur in 499 adults from the 2013-2014 National Health and Nutrition Examination Survey (NHANES). Methods: We used BWQS to assess the combined association of nine PFAS, as a mixture, with bone mineral density in adults. As secondary analyses, we focused on vulnerable populations (men over 50 years and postmenopausal women). Analyses were weighted according to NHANES weights and were adjusted for socio-demographic factors. Sensitivity analyses included bone mineral density associations with individual compounds and results from WQS regressions. Results: The mean age was 55 years old (Standard Error [SE]=1) with average spine, total and neck femur mineral densities of 1.01 (SE=0.01), 0.95 (SE=0.01), and 0.78 (SE=0.01) gm/cm2, respectively. PFAS mixture levels showed no evidence of association with mineral density (spine: Beta=-0.004; 95% credible interval [CrI]=-0.04, 0.04; total femur: Beta=0.002; 95%CrI=-0.04, 0.05; femur neck: Beta=0.005; 95%CrI=-0.03, 0.04) in the overall population. Results were also null in vulnerable populations. Findings were consistent across sensitivity analyses. Conclusions: We introduced a Bayesian extension of WQS and found no evidence of the association between PFAS mixture and bone mineral density. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This research was supported by grant P30ES023515, U2CES026444, UH3OD023337-03 of the National Institute of Environmental Health Sciences of the National Institutes of Health. The authors would like to thank Dr. Christine Schubert Kabban for helpful comments. ### Author Declarations All relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript. Yes All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes Data are available on the Centers for Disease Control and Prevention (CDC)s website (National Health and Nutrition Examination Survey cycle 2013-2014). | |
| Cold Spring Harbor Laboratory Press | |
| 2019 | |
| Preimpreso | |
| https://www.medrxiv.org/content/10.1101/19010710v1 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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| Per and poly fluoroalkyl.pdf | 1.87 MB | Adobe PDF | Visualizar/Abrir |