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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/258| Estimating maximal oxygen consumption from heart rate response to submaximal ramped treadmill test | |
| Tomas I. Gonzales Kate Westgate Stefanie Hollidge Justin Jeon Soren Brage Tim Lindsay | |
| Novel Coronavirus | |
| Acceso Abierto | |
| Atribución-SinDerivadas | |
| 10.1101/2020.02.18.20024489 | |
| The Cambridge Ramped Treadmill Test (CRTT) is an incremental, multistage exercise test (I: steady-state walk, II: walk ramped speed, III: walk ramped incline, and IV: run ramped speed on flat). It is typically deployed as a submaximal test with flexible test termination criteria, making it an attractive option for population-based studies of cardiorespiratory fitness. We conducted a study in healthy adults to test the validity of maximal oxygen consumption estimates (VO2max; ml O2 · kg-1 · min-1) predicted from CRTT heart rate response using several methods: a heart rate-to-work rate linear regression method across several test termination criteria, either when a percentage of age-predicted maximal heart rate was achieved (50% through 100%) or at the end of distinct CRTT stages (II, III, and IV); and two single-point walk-test calibration methods using data from either CRTT stage I (low-point method) or stage II (high-point method). For estimates from the linear regression method, prediction bias ranged from -3.0 to -1.6 ml O2 · kg-1 · min-1 and Pearson's r ranged from 0.57 to 0.79 for endpoints at percentages of age-predicted maximal heart rate; results were similar for stages III and IV endpoints, but predictions using data only up to stage II had poorer agreement. Agreement was moderate when using the low-point (mean bias: -4.3ml O2 · kg-1 · min-1; Pearson's r: 0.71) and high-point (mean bias: -3.5 ml O2 · kg-1 · min-1; Pearson's r: 0.69) methods. Heart rate response to the CRTT can be used to predict VO2max with acceptable validity in common epidemiological scenarios. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This research was supported by the Medical Research Council Epidemiology Unit (MC_UU_12015/3) and the NIHR Cambridge Biomedical Research Centre (IS-BRC-1215-20014). ### Author Declarations All relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript. Yes All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes The data analysed during the current study are not publicly available because we have not obtained consent for public data sharing from the study participants; however data can be made available for analysis upon reasonable request to the corresponding author. | |
| Cold Spring Harbor Laboratory Press | |
| 2020 | |
| Preimpreso | |
| https://www.medrxiv.org/content/10.1101/2020.02.18.20024489v1 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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