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Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses.
Letko Michael.
Marzi Andrea.
Munster Vincent.
Acceso Abierto
Atribución-NoComercial-SinDerivadas
10.1038/s41564-020-0688-y
This study describes the development of an approach to rapidly screen lineage B betacoronaviruses, such as SARS-CoV and the recently emerged SARS-CoV-2, for receptor usage and their ability to infect cell types from different species. Using it, they confirm human ACE2 as the receptor for SARs-CoV-2 and show that host protease processing during viral entry is a significant barrier for viral entry.
Nature Microbiology
2020
Artículo
https://www.nature.com/articles/s41564-020-0688-y.pdf
Inglés
VIRUS RESPIRATORIOS
Aparece en las colecciones: Artículos científicos

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