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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/2432| Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools. | |
| Fu Yajing. Cheng Yuanxiong. Wu Yuntao. | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1007/s12250-020-00207-4 | |
| Currently there is no effective antiviral therapy for SARS-CoV-2 infection, which frequently leads to fatal inflammatory responses and acute lung injury. Here, we discuss the various mechanisms of SARS-CoV-mediated inflammation. We also assume that SARS-CoV-2 likely shares similar inflammatory responses. Potential therapeutic tools to reduce SARS-CoV-2-induced inflammatory responses include various methods to block FcR activation. In the absence of a proven clinical FcR blocker, the use of intravenous immunoglobulin to block FcR activation may be a viable option for the urgent treatment of pulmonary inflammation to prevent severe lung injury. Such treatment may also be combined with systemic anti-inflammatory drugs or corticosteroids. However, these strategies, as proposed here, remain to be clinically tested for effectiveness. | |
| Virologica Sinica | |
| 2020 | |
| Artículo | |
| https://link.springer.com/content/pdf/10.1007/s12250-020-00207-4.pdf | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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