Please use this identifier to cite or link to this item: https://covid-19.conacyt.mx/jspui/handle/1000/2373
Genomic epidemiology of SARS-CoV-2 in Guangdong Province, China
Jing Lu.
Louis du Plessis.
Zhe Liu.
Verity Hill.
Min Kang.
Huifang Lin.
Jiufeng Sun.
Sarah Francois.
Moritz U G Kraemer.
Nuno R Faria.
John T McCrone.
Jinju Peng.
Qianling Xiong.
Runyu Yuan.
Lilian Zeng.
Pingping Zhou.
Chuming Liang.
Lina Yi.
Jun Liu.
Jianpeng Xiao.
Jianxiong Hu.
Tao Liu.
Wenjun Ma.
Wei Li.
Juan Su.
Huanying Zheng.
Bo Peng.
Shisong Fang.
Wenzhe Su.
Kuibiao Li.
Ruilin Sun.
Ru Bai.
Xi Tang.
Minfeng Liang.
Josh Quick.
Tie Song.
Andrew Rambaut.
Nick Loman.
Jayna Raghwani.
Oliver Pybus.
Changwen Ke.
Acceso Abierto
Atribución-NoComercial-SinDerivadas
10.1101/2020.04.01.20047076
Highlights: 1) 1.6 million molecular diagnostic tests identified 1,388 SARS-CoV-2 infections in Guangdong Province, China, by 19th March 2020; 2) Virus genomes can be recovered using a variety of sequencing approaches from a range of patient samples. 3) Genomic analyses reveal multiple virus importations into Guangdong Province, resulting in genetically distinct clusters that require careful interpretation. 4) Large-scale epidemiological surveillance and intervention measures were effective in interrupting community transmission in Guangdong Summary: COVID-19 is caused by the SARS-CoV-2 coronavirus and was first reported in central China in December 2019. Extensive molecular surveillance in Guangdong, China's most populous province, during early 2020 resulted in 1,388 reported RNA positive cases from 1.6 million tests. In order to understand the molecular epidemiology and genetic diversity of SARS-CoV-2 in China we generated 53 genomes from infected individuals in Guangdong using a combination of metagenomic sequencing and tiling amplicon approaches. Combined epidemiological and phylogenetic analyses indicate multiple independent introductions to Guangdong, although phylogenetic clustering is uncertain due to low virus genetic variation early in the pandemic. Our results illustrate how the timing, size and duration of putative local transmission chains were constrained by national travel restrictions and by the province's large-scale intensive surveillance and intervention measures. Despite these successes, COVID-19 surveillance in Guangdong is still required as the number of cases imported from other countries is increasing.
www.medrxiv.org
2020
Artículo
https://www.medrxiv.org/content/10.1101/2020.04.01.20047076v1.full.pdf
Inglés
VIRUS RESPIRATORIOS
Appears in Collections:Artículos científicos

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