Por favor, use este identificador para citar o enlazar este ítem:
http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/2361| Human SARS-CoV-2 has evolved to reduce CG dinucleotide in its open reading frames | |
| Wang Yong. Mao Jun-Ming. Wang Guang-Dong. Qiu Ze. Yao Qin. Chen Ke-Ping. | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.21203/rs.3.rs-21003/v1 | |
| The causative agent of COVID-19 is a severe acute respiratory syndrome-related coronavirus which has been officially named SARS-CoV-2. Here we report the discovery of extremely low CG abundance in its open reading frames. We found that CG reduction in SARS-CoV-2 is achieved mainly through mutating C/G into A/T, and CG is the best target for mutation. In view of energy usage, a coronavirus with low CG abundance has higher efficiency in translating its RNA, because the secondary structure formed by viral genome is less stable. 5’-untranslated region of SARS-CoV-2 has much more CGs and is capable of recruiting host ribosomes to initiate translation. Notably, genomes of cellular organisms also have very low CG abundance, suggesting that mutating C/G into A/T occurs universally in all life forms. Moreover, CG is related to mutational hotspots and CpG islands in cellular organisms. The relationship between them is worthy of further investigations. | |
| assets.researchsquare.com | |
| 2020 | |
| Artículo | |
| https://assets.researchsquare.com/files/rs-21003/v1/manuscript.pdf | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
Cargar archivos:
| Fichero | Tamaño | Formato | |
|---|---|---|---|
| 1101522.pdf | 339.69 kB | Adobe PDF | Visualizar/Abrir |