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Urgent Guidance for Navigating and Circumventing the QTc-Prolonging and Torsadogenic Potential of Possible Pharmacotherapies for Coronavirus Disease 19 (COVID-19)
Giudicessi John R..
Noseworthy Peter A..
Friedman Paul A..
Ackerman Michael J..
Acceso Abierto
Atribución-NoComercial-SinDerivadas
10.1016/j.mayocp.2020.03.024
As the coronavirus disease 19 (COVID-19) global pandemic rages across the globe, the race to prevent and treat this deadly disease has led to the “off-label” repurposing of drugs such as hydroxychloroquine and lopinavir/ritonavir, which has the potential for unwanted QT-interval prolongation and a risk of drug-induced sudden cardiac death. With the possibility that a considerable proportion of the world’s population soon could receive COVID-19 pharmacotherapies with torsadogenic potential for therapy or postexposure prophylaxis, this document serves to help health care professionals mitigate the risk of drug-induced ventricular arrhythmias while minimizing risk of COVID-19 exposure to personnel and conserving the limited supply of personal protective equipment.
Mayo Clinic Proceedings
2020
Artículo
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141471/pdf/main.pdf
Inglés
VIRUS RESPIRATORIOS
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