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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/2088| COVID-19 Coronavirus spike protein analysis for synthetic vaccines, a peptidomimetic antagonist, and therapeutic drugs, and analysis of a proposed achilles’ heel conserved region to minimize probability of escape mutations and drug resistance | |
| Robson B.. | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1016/j.compbiomed.2020.103749 | |
| Highlights•This paper “drills down” into the studies of the author's previous COVID-19 paper.•Designing vaccine and drugs must seek to avoid escape mutations.•Subsequence KRSFIEDLLFNKV seems recognizable across many coronaviruses.•The ACE2 binding domain is a target, but shows variation.•A steroid dehydrogenase is argued to remain an interesting model pharmacophore. | |
| Computers in Biology and Medicine | |
| 2020 | |
| Artículo | |
| https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151553/pdf/main.pdf | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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| Fichero | Tamaño | Formato | |
|---|---|---|---|
| 1101037.pdf | 1.83 MB | Adobe PDF | Visualizar/Abrir |