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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/1980| The differential expression of the ACE2 receptor across ages and gender explains the differential lethality of SARS-Cov-2 and suggests possible therapy | |
| Ugo Bastolla. | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://arxiv.org/pdf/2004.07224v1.pdf | |
| There are striking differences in the lethality of the Covid-19 disease, from more than 90% estimated infected persons that experience only very weak or no symptoms to cases that require ICU assistance and result in death. The fatality rate escalates dramatically with age and is much larger in males than in females. I show here these dramatic variations in fatality rates across age and gender are impressively strongly correlated ($r^2=0.91$ with only one free parameter) with levels of the ACE2 protein in rat lungs, which are in turn qualitatively similar to expression in humans. This behaviour is predicted by a model that assumes that deaths are caused by the degradation of the ACE2 receptor by the virus, which uses it as entry point in the cells. The insufficient level of ACE2 exacerbates the inflammatory response eventually leading to death, but if the initial levels of ACE2 are high the immune system has enough time to resolve the infection before it gets to extreme consequences. These results are consistent with previous hypothesis on the protective role of ACE2, and suggest that, counterintuitively, drugs that act synergistically with ACE2 and enhance its expression, such as ACE inhibitors and angiotensin receptor blockers used to treat high blood pressure, may offer a promising therapy against the most adverse effects of the Covid-19 disease. ACE2 is also candidate to be a prognostic factor and a risk factor for detecting population that needs stronger protection. | |
| arxiv.org | |
| 2020 | |
| Artículo | |
| https://arxiv.org/pdf/2004.07224v1.pdf | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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