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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/1963| HLA predictions from the bronchoalveolar lavage fluid samples of five patients at the early stage of the Wuhan seafood market COVID-19 outbreak | |
| Rene L Warren. Inanc Birol. | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://arxiv.org/pdf/2004.07108v1.pdf | |
| We are in the midst of a global viral pandemic, one with no cure and a high mortality rate. The Human Leukocyte Antigen (HLA) gene complex plays a critical role in host immunity. We predicted HLA class I alleles from the transcriptome sequencing data prepared from the bronchoalveolar lavage fluid samples of five patients at the early stage of the COVID-19 outbreak. We identified the HLA-I allele A*24:02 in four out of five patients, which is higher than the expected frequency (17.2%) in the South Han Chinese population. The difference is statistically significant with a p-value less than $10^{-4}$. Our analysis results may help provide future insights on disease susceptibility. | |
| arxiv.org | |
| 2020 | |
| Artículo | |
| https://arxiv.org/pdf/2004.07108v1.pdf | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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