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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/1885| Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates | |
| Damas Joana. Hughes Graham. Keough Kathleen. Painter Corrie. Persky Nicole. Corbo Marco. Hiller Michael. Koepfli Klaus-Peter. Pfenning Andreas. Zhao Huabin. Genereux Diane. Swofford Ross. Pollard Katherine. Ryder Oliver. Nweeia Martin. Lindblad-Toh Kerstin. Teeling Emma. Karlsson Elinor. Lewin Harris. | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1101/2020.04.16.045302 | |
| The novel coronavirus SARS-CoV-2 is the cause of Coronavirus Disease-2019 (COVID-19). As for other coronaviruses, there is transmission between animals and humans. The main receptor of SARS-CoV-2, angiotensin I converting enzyme-2 (ACE2), is now undergoing extensive scrutiny to understand the routes of transmission and sensitivity in different species. Here, we utilized a unique dataset of 410 vertebrates, including 252 mammals, to study cross-species conservation of ACE2 and its likelihood to function as a SARS-CoV-2 receptor. We designed a five-category ranking scheme based on the conservation properties of 25 amino acids important for the binding between receptor and virus, classifying all species from very high to very low. Only mammals fell into the medium to very high categories, and only catarrhine primates in the very high category, suggesting that they are at high risk for SARS-CoV-2 infection. We employed a structural analysis to qualitatively assess whether amino acid changes at variable residues would be likely to disrupt ACE2/SARS-CoV-2 binding, and found the number of predicted unfavorable changes significantly correlated with the risk classification. Extending this analysis to human population data, we found only rare ( | |
| www.biorxiv.org | |
| 2020 | |
| Artículo | |
| https://www.biorxiv.org/content/biorxiv/early/2020/04/18/2020.04.16.045302.full.pdf | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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| 1100292.pdf | 1.92 MB | Adobe PDF | Visualizar/Abrir |