Please use this identifier to cite or link to this item: https://covid-19.conacyt.mx/jspui/handle/1000/1820
Natural products may interfere with SARS-CoV-2 attachment to the host cell
Elfiky Abdo.
Acceso Abierto
Atribución-NoComercial-SinDerivadas
10.21203/rs.3.rs-22458/v1
Objectives: SARS-CoV-2 has been emerged in December 2019 in China, causing deadly (5% mortality) pandemic pneumonia, termed COVID-19. More than one host-cell receptor is reported to be recognized by the viral spike protein, among them is the cell-surface Heat Shock Protein A5 (HSPA5), also termed GRP78 or BiP. Upon viral infection, HSPA5 is upregulated, then translocating to the cell membrane where it is subjected to be recognized by the SARS-CoV-2 spike. In this study, some natural product compounds are tested against the HSPA5 substrate-binding domain β (SBDβ), which reported to be the recognition site for the SARS-CoV-2 spike. Methods: Molecular docking and molecular dynamics simulations are used to test some natural compounds binding to HSPA5 SBDβ. Results: The results show high to a moderate binding affinity for the phytoestrogens (Diadiazin, Genistein, Formontein, and Biochanin A), chlorogenic acid, linolenic acid, palmitic acid, caffeic acid, caffeic acid phenethyl ester, hydroxytyrosol, cis-p-Coumaric acid, cinnamaldehyde, and thymoquinone to the HSPA5 SBDβ. Based on its binding affinities, the natural compounds, and some hormones, may interfere with SARS-CoV-2 attachment to the stressed cells. Conclusion: These compounds can be successful as anti-COVID-19 agents for people with a high risk of cell stress like elders, cancer patients, and front-line medical staff.
assets.researchsquare.com
2020
Artículo
https://assets.researchsquare.com/files/rs-22458/v1/manuscript.pdf
Inglés
VIRUS RESPIRATORIOS
Appears in Collections:Artículos científicos

Upload archives


File SizeFormat 
1100190.pdf1.05 MBAdobe PDFView/Open