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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/177| Regaining perspective on SARS-CoV-2 molecular tracing and its implications | |
| Mattia Prosperi Marco Salemi Ilaria Capua Costanza Manes Carla Mavian Simone Marini | |
| Novel Coronavirus | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1101/2020.03.16.20034470 | |
| During the past three months, a new coronavirus (SARS-CoV-2) epidemic has been growing exponentially, affecting over 100 thousand people worldwide, and causing enormous distress to economies and societies of affected countries. A plethora of analyses based on viral sequences has already been published, in scientific journals as well as through non-peer reviewed channels, to investigate SARS-CoV-2 genetic heterogeneity and spatiotemporal dissemination. We examined all full genome sequences currently available to assess the presence of sufficient information for reliable phylogenetic and phylogeographic studies. Our analysis clearly shows severe limitations in the present data, in light of which any finding should be considered, at the very best, preliminary and hypothesis-generating. Hence the need for avoiding stigmatization based on partial information, and for continuing concerted efforts to increase number and quality of the sequences required for robust tracing of the epidemic. ### Competing Interest Statement Ilaria Capua was a member of the Italian Parliament (2013-2016). ### Funding Statement No external funding was received ### Author Declarations All relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript. Yes All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes Genomes were downloaded from GISAID https://www.gisaid.org/, a list of the genomes used is available in the supplementary material. Data about confirmed cases were obtained from "Coronavirus COVID-19 Global Cases" by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU) <https://www.gisaid.org/> <https://github.com/CSSEGISandData/COVID-19> | |
| Cold Spring Harbor Laboratory Press | |
| 2020 | |
| Preimpreso | |
| https://www.medrxiv.org/content/10.1101/2020.03.16.20034470v1 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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| Fichero | Tamaño | Formato | |
|---|---|---|---|
| Regaining perspective on SARS.pdf | 1.58 MB | Adobe PDF | Visualizar/Abrir |