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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/1752| Bioinformatics approaches to understand the interactions between the SARS corona Virus (SARS-CoV19) with stranded drugs of anti-retro viral treatment, Influenza and Malaria. | |
| perugu Shyam. Nanchari Santhoshi Rani. | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.21203/rs.3.rs-20010/v1 | |
| Background: Severe acute respiratory syndrome (SARS) is highly contagious disease caused by virus COVID19. The first case is reported in Wuhan, China, with rapid spreading all over the world and the rate of mortality is also high. SARS-CoV and another human coronavirus, HCoV-NL63 has large spike protein (S) on the virion surface mediates both cell attachment and membrane fusion with receptor sites present on host cell-surface zinc peptidase, angiotensin-converting enzyme 2 (ACE2). Methodology: In the present study, molecular docking studies have been carried out to assess the interaction between the novel corona virus protein COVID19 with stranded drugs used for influenza, anti-retro viral therapy and malaria drugs by using Accelerys discovery studio 2.5, followed by analysis of data. The present study will help to design the drugs against the corona virus and understand the mode of treatment for SARS. Results: All the four-protein receptor of COVID 19 proteins at particular amino acid position binds to the NH and H atom of anti-retro viral therapy drugs (Atazanavir, Doravirine, Emitricitabine, Entravirine, Raltegravir, Tenofavir Disproxil, and Zidovudin) and anti-malaria drug (Hydroxy chloroquine) with less hydrogen bond distance with maximum docking scores which indicates that these compounds can acts against the COVID19 virus. Gene mania network help to design the novel drugs and diagnosis. Conclusions: This is first report to show the molecular docking interaction between the COVID19 protein with stranded drugs of anti -viral treatment. anti-viral drugs Atazanavir, Doravirine, Emitricitabine, Entravirine, Raltegravir, Tenofavir Disproxil, and Zidovudin and malaria drug Hydroxy chloroquine has more strong binding with COVID19 protein receptors. | |
| assets.researchsquare.com | |
| 2020 | |
| Artículo | |
| https://assets.researchsquare.com/files/rs-20010/v1/manuscript.pdf | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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