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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/1734| Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients | |
| Yong Xiong Yuan Liu Liu Cao Dehe Wang Ming Guo Ao Jiang Dong Guo Jiayi Yang Zhidong Tang Yongquan Lin Qi Zhang Mang Shi Yingle Liu Yu Zhou Ke Lan Yu Chen | |
| Acceso Abierto | |
| Atribución | |
| https://doi.org/10.1080/22221751.2020.1747363 | |
| Transcriptome profiling Inflammation Cytokine Lymphopenia | |
| Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortalityand posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. Tocharacterize the transcriptional signatures of host inflammatory response to SARS-CoV-2 (HCoV-19) infection, we carried out transcriptome sequencing of the RNAs isolated from the bronchoalveolar lavagefluid (BALF) and peripheral blood mononuclear cells (PBMC) specimens of COVID-19 patients. Our results reveal distinct host inflammatory cytokine profiles to SARS-CoV-2 infection in patients, and highlight the association between COVID-19 pathogenesis and excessive cytokine release such as CCL2/MCP-1, CXCL10/IP-10, CCL3/MIP-1A, and CCL4/MIP1B. Furthermore, SARS-CoV-2 induced activation of apoptosis and P53 signalling pathway in lymphocytes may be thecause of patients’lymphopenia. The transcriptome data set of COVID-19 patients would be a valuable resource forclinical guidance on anti-inflammatory medication and understanding the molecular mechansims of host response. | |
| Emerging Microbes & Infections | |
| 31-03-2020 | |
| Artículo | |
| https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1747363 | |
| Inglés | |
| Epidemia COVID-19 | |
| Investigadores | |
| VIRUS RESPIRATORIOS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | Artículos científicos |
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| Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.pdf | 3.4 MB | Adobe PDF | Visualizar/Abrir |