Please use this identifier to cite or link to this item: https://covid-19.conacyt.mx/jspui/handle/1000/1724
A Review of SARS-CoV-2 and the Ongoing Clinical Trials
Yung-Fang Tu
Chian-Shiu Chien
Aliaksandr A. Yarmishyn
Yi-Ying Lin
Yung-Hung Luo
Yi-Tsung Lin
De-Ming Yang
Yi-Ping Yang
Mong-Lien Wang
Shih_Hwa Chiou
Acceso Abierto
Atribución
https://doi.org/10.3390/ijms21072657
SARS-CoV-2
COVID-19
Pneumonia
Clinical trials
Immunotherapy
Vaccine
The sudden outbreak of 2019 novel coronavirus (2019-nCoV, later named SARS-CoV-2) in Wuhan, China, which rapidly grew into a global pandemic, marked the third introduction of a virulent coronavirus into the human society, affecting not only the healthcare system, but also the global economy. Although our understanding of coronaviruses has undergone a huge leap after two precedents, the effective approaches to treatment and epidemiological control are still lacking. In this article, we present a succinct overview of the epidemiology, clinical features, and molecular characteristics of SARS-CoV-2. We summarize the current epidemiological and clinical data from the initial Wuhan studies, and emphasize several features of SARS-CoV-2, which differentiate it from SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), such as high variability of disease presentation. We systematize the current clinical trials that have been rapidly initiated after the outbreak of COVID-19 pandemic. Whereas the trials on SARS-CoV-2 genome-based specific vaccines and therapeutic antibodies are currently being tested, this solution is more long-term, as they require thorough testing of their safety. On the other hand, the repurposing of the existing therapeutic agents previously designed for other virus infections and pathologies happens to be the only practical approach as a rapid response measure to the emergent pandemic, as most of these agents have already been tested for their safety. These agents can be divided into two broad categories, those that can directly target the virus replication cycle, and those based on immunotherapy approaches either aimed to boost innate antiviral immune responses or alleviate damage induced by dysregulated inflammatory responses. The initial clinical studies revealed the promising therapeutic potential of several of such drugs, including favipiravir, a broad-spectrum antiviral drug that interferes with the viral replication, and hydroxychloroquine, the repurposed antimalarial drug that interferes with the virus endosomal entry pathway. We speculate that the current pandemic emergency will be a trigger for more systematic drug repurposing design approaches based on big data analysis.
International Journal of Molecular Sciences
10-04-2020
Artículo
https://www.mdpi.com/1422-0067/21/7/2657/htm
Inglés
Epidemia COVID-19
Investigadores
VIRUS RESPIRATORIOS
Versión publicada
publishedVersion - Versión publicada
Appears in Collections:Artículos científicos

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