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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/1647| Distinct mutation in the feline coronavirus spike protein cleavage activation site in a cat with feline infectious peritonitis-associated meningoencephalomyelitis | |
| André, N Cossic, B Davies, E Miller, A Whittaker, G | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| Case summary: This report describes a cat with chronic, progressive, non-painful, non-lateralizing multifocal neurologic clinical signs associated with feline infectious peritonitis (FIP). The cat initially presented as underweight, despite a good appetite, and a complete blood count showed non-regenerative anemia. Three months later the cat was returned having developed ataxia and paraparesis, which then progressed over 2 months to tetraparesis, tail plegia, urinary and fecal incontinence, and titubation. Histologic examination of the tissues with subsequent immunohistochemistry confirmed FIP-associated meningoencephalomyelitis following necropsy. Molecular analysis of the coronavirus spike protein within the tissues identified a specific, functionally relevant amino acid change (R793M), which was only identified in tissues associated with the central nervous system (ie, brain and spinal cord).Relevance and novel information: This case report describes an early presentation of a cat with primarily neurologic FIP, with molecular characterization of the virus within various tissues. | |
| Journal of Feline Medicine and Surgery Open Reports | |
| 2019 | |
| Preimpreso | |
| https://coronavirus.1science.com/item/278998a06732b9d86da6c29b1664c11e58d6c4c4 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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