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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/1551| Shared common ancestry of rodent alphacoronaviruses sampled globally | |
| Tsoleridis, T Chappell, J Onianwa, O Marston, D Fooks, A Monchatre-Leroy, E Umhang, G Müller, M Drexler, J Drosten, C Tarlinton, R McClure, C Holmes, E Ball, J | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| The recent discovery of novel alphacoronaviruses (alpha-CoVs) in European and Asian rodents revealed that rodent coronaviruses (CoVs) sampled worldwide formed a discrete phylogenetic group within this genus. To determine the evolutionary history of rodent CoVs in more detail, particularly the relative frequencies of virus-host co-divergence and cross-species transmission, we recovered longer fragments of CoV genomes from previously discovered European rodent alpha-CoVs using a combination of PCR and high-throughput sequencing. Accordingly, the full genome sequence was retrieved from the UK rat coronavirus, along with partial genome sequences from the UK field vole and Poland-resident bank vole CoVs, and a short conserved ORF1b fragment from the French rabbit CoV. Genome and phylogenetic analysis showed that despite their diverse geographic origins, all rodent alpha-CoVs formed a single monophyletic group and shared similar features, such as the same gene constellations, a recombinant beta-CoV spike gene, and similar core transcriptional regulatory sequences (TRS). These data suggest that all rodent alpha CoVs sampled so far originate from a single common ancestor, and that there has likely been a long-term association between alpha CoVs and rodents. Despite this likely antiquity, the phylogenetic pattern of the alpha-CoVs was also suggestive of relatively frequent host-jumping among the different rodent species. | |
| Viruses | |
| 2019 | |
| Preimpreso | |
| https://coronavirus.1science.com/item/b377c7a8f7183232dbad57d3d8991e0b874d9186 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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