Please use this identifier to cite or link to this item: https://covid-19.conacyt.mx/jspui/handle/1000/1551
Shared common ancestry of rodent alphacoronaviruses sampled globally
Tsoleridis, T
Chappell, J
Onianwa, O
Marston, D
Fooks, A
Monchatre-Leroy, E
Umhang, G
Müller, M
Drexler, J
Drosten, C
Tarlinton, R
McClure, C
Holmes, E
Ball, J
Acceso Abierto
Atribución-NoComercial-SinDerivadas
The recent discovery of novel alphacoronaviruses (alpha-CoVs) in European and Asian rodents revealed that rodent coronaviruses (CoVs) sampled worldwide formed a discrete phylogenetic group within this genus. To determine the evolutionary history of rodent CoVs in more detail, particularly the relative frequencies of virus-host co-divergence and cross-species transmission, we recovered longer fragments of CoV genomes from previously discovered European rodent alpha-CoVs using a combination of PCR and high-throughput sequencing. Accordingly, the full genome sequence was retrieved from the UK rat coronavirus, along with partial genome sequences from the UK field vole and Poland-resident bank vole CoVs, and a short conserved ORF1b fragment from the French rabbit CoV. Genome and phylogenetic analysis showed that despite their diverse geographic origins, all rodent alpha-CoVs formed a single monophyletic group and shared similar features, such as the same gene constellations, a recombinant beta-CoV spike gene, and similar core transcriptional regulatory sequences (TRS). These data suggest that all rodent alpha CoVs sampled so far originate from a single common ancestor, and that there has likely been a long-term association between alpha CoVs and rodents. Despite this likely antiquity, the phylogenetic pattern of the alpha-CoVs was also suggestive of relatively frequent host-jumping among the different rodent species.
Viruses
2019
Preimpreso
https://coronavirus.1science.com/item/b377c7a8f7183232dbad57d3d8991e0b874d9186
Inglés
VIRUS RESPIRATORIOS
Appears in Collections:Artículos científicos

Upload archives


File SizeFormat 
110071.pdf3.6 MBAdobe PDFView/Open