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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/149| The role of the environment in overweight and eating behavior variability: Insights from a multivariate twin study. | |
| Moritz Herle Juan J Madrid-Valero Jose J Morosoli Lucia Colodro Conde Juan R Ordonana | |
| Novel Coronavirus | |
| Acceso Abierto | |
| Atribución-NoComercial | |
| 10.1101/2020.03.23.20041384 | |
| The health consequences of overweight and obesity remain one of the greatest global health challenges. Twin and molecular studies have confirmed the genetic basis of individual differences in BMI; however, genetics cannot explain the rapid rise of obesity rates over the past decades. Eating behaviors have been stipulated to be the behavioral expression of genetic risk in an obesogenic environment. Multivariate twin studies can inform future applied research by providing insights into the etiology of the relationship between behaviors and BMI. In this study, we aimed to decompose variation and covariation between three key eating behaviors and BMI in a sample from a population-based twin registry of adult women in the southeast of Spain, The Murcia Twin Registry (345 complete, 9 incomplete, same sex female twin pairs, 175 MZ, 170 DZ). Phenotypes were emotional eating, uncontrolled eating, and cognitive restraint, as measured by the Three Factor Eating Questionnaire, as well as objectively measured BMI. Variation in eating behaviors was mostly driven by non-shared environmental factors (range: 56, 65%), whereas shared environmental and genetic factors were secondary. All three eating behaviors were associated with BMI at a phenotypic level (range r=0.19, 0.25). Etiological correlations implied that non-shared environmental factors underlie the covariations of the phenotypes (Emotional eating & Uncontrolled eating: rE= 0.54, 95%CI: 0.43, 0.64; BMI & Cognitive restraint: rE= 0.15, 95%CI: 0.01, 0.28). Results indicate that in contrast to BMI, individual differences in eating behaviors are mostly explained by non-shared environmental factors, which also account for the phenotypic correlation between eating behaviors and BMI. These results support that eating behaviors are viable intervention targets to help individuals reach and maintain a healthy weight. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement The MTR is being funded by Seneca Foundation Regional Agency for Science and Technology, Murcia, Spain (grants 03082/PHCS/05, 08633/PHCS/08, 15302/PHCS/10 and 19479/PI/14) and the Spanish Ministry of Science and Innovation (PSI200911560 and PSI2014-56680-R). Dr Herle is funded by fellowship from the Medical Research Council UK (MR/T027843/1). Dr Colodro-Conde is supported by a QIMR Berghofer fellowship. ### Author Declarations All relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript. Yes All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes Data can be requested from the authors. All analytical code is stored here: https://github.com/MoritzHerle/The-role-of-the-environment-in-overweight-and-eating-behavior-variability | |
| Cold Spring Harbor Laboratory Press | |
| 2020 | |
| Preimpreso | |
| https://www.medrxiv.org/content/10.1101/2020.03.23.20041384v1 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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