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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/1428| Evolutionary relationship analysis of Middle East respiratory syndrome coronavirus 4a and 4b protein coding sequences | |
| Kim, J Park, S Bae, J Park, M | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| The 4a and 4b proteins of the Middle East respiratory syndrome coronavirus (MERS-CoV) have been described for their antagonism on host innate immunity. However, unlike clustering patterns of the complete gene sequences of human and camel MERS-CoVs, the 4a and 4b protein coding regions did not constitute species-specific phylogenetic groups. Moreover, given the estimated evolutionary rates of the complete, 4a, and 4b gene sequences, the 4a and 4b proteins might be less affected by species-specific innate immune pressures. These results suggest that the 4a and 4b proteins of MERS-CoV may function against host innate immunity in a manner independent of host species and/or evolutionary clustering patterns. | |
| Journal of Veterinary Science | |
| 2019 | |
| Preimpreso | |
| https://coronavirus.1science.com/item/79392fdb22e169cb1989066b8d1fec22b6e25cae | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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| 108831.pdf | 6.46 MB | Adobe PDF | Visualizar/Abrir |