Please use this identifier to cite or link to this item: https://covid-19.conacyt.mx/jspui/handle/1000/1406
Efficacy of an adjuvanted middle east respiratory syndrome coronavirus spike protein vaccine in dromedary camels and alpacas
Adney, D
Wang, L
Van Doremalen, N
Shi, W
Zhang, Y
Kong, W
Miller, M
Bushmaker, T
Scott, D
de Wit, E
Modjarrad, K
Petrovsky, N
Graham, B
Bowen, R
Munster, V
Acceso Abierto
Atribución-NoComercial-SinDerivadas
MERS-CoV is present in dromedary camels throughout the Middle East and Africa. Dromedary camels are the primary zoonotic reservoir for human infections. Interruption of the zoonotic transmission chain from camels to humans, therefore, may be an effective strategy to control the ongoing MERS-CoV outbreak. Here we show that vaccination with an adjuvanted MERS-CoV Spike protein subunit vaccine confers complete protection from MERS-CoV disease in alpaca and results in reduced and delayed viral shedding in the upper airways of dromedary camels. Protection in alpaca correlates with high serum neutralizing antibody titers. Lower titers of serum neutralizing antibodies correlate with delayed and significantly reduced shedding in the nasal turbinates of dromedary camels. Together, these data indicate that induction of robust neutralizing humoral immune responses by vaccination of naïve animals reduces shedding that potentially could diminish the risk of zoonotic transmission.
Viruses
2019
Preimpreso
https://coronavirus.1science.com/item/fc8d600f2ace8b8bb11d1caff62db72b4ab89407
Inglés
VIRUS RESPIRATORIOS
Appears in Collections:Artículos científicos

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