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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/1326| Potent MERS-CoV fusion inhibitory peptides identified from HR2 domain in spike protein of bat coronavirus HKU4 | |
| Xia, S Lan, Q Pu, J Wang, C Liu, Z Xu, W Wang, Q Liu, H Jiang, S Lu, L | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| The Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 and caused continual outbreaks worldwide with high mortality. However, no effective anti-MERS-CoV drug is currently available. Recently, numerous evolutionary studies have suggested that MERS-CoV originated from bat coronavirus (BatCoV). We herein reported that three peptides derived from the HR2 region in spike protein of BatCoV HKU4, including HKU4-HR2P1, HKU4-HR2P2 and HKU4-HR2P3, could bind the MERS-CoV HR1-derived peptide to form a six-helix bundle (6-HB) with high stability. Moreover, these peptides, particularly HKU4-HR2P2 and HKU4-HR2P3, exhibited potent inhibitory activity against MERS-CoV S-mediated cell⁻cell fusion and viral infection, suggesting that these HKU4 HR2-derived peptides could be candidates for futher development as antiviral agents against MERS-CoV infection. | |
| Viruses | |
| 2019 | |
| Preimpreso | |
| https://coronavirus.1science.com/item/e6049aad94858a262651cbaff903a652af4c2485 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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