Please use this identifier to cite or link to this item: https://covid-19.conacyt.mx/jspui/handle/1000/1315
Novel bat alphacoronaviruses in Southern China support chinese horseshoe bats as an important reservoir for potential novel coronaviruses
Lau, S
Wong, A
Zhang, L
Luk, H
Kwok, J
Ahmed, S
Cai, J
Zhao, P
Teng, J
Tsui, S
Yuen, K
Woo, P
Acceso Abierto
Atribución-NoComercial-SinDerivadas
While bats are increasingly recognized as a source of coronavirus epidemics, the diversity and emergence potential of bat coronaviruses remains to be fully understood. Among 1779 bat samples collected in China, diverse coronaviruses were detected in 32 samples from five different bat species by RT-PCR. Two novel alphacoronaviruses, Rhinolophus sinicus bat coronavirus HKU32 (Rs-BatCoV HKU32) and Tylonycteris robustula bat coronavirus HKU33 (Tr-BatCoV HKU33), were discovered from Chinese horseshoe bats in Hong Kong and greater bamboo bats in Guizhou Province, respectively. Genome analyses showed that Rs-BatCoV HKU32 is closely related to BatCoV HKU10 and related viruses from diverse bat families, whereas Tr-BatCoV HKU33 is closely related to BtNv-AlphaCoV and similar viruses exclusively from bats of Vespertilionidae family. The close relatedness of Rs-BatCoV HKU32 to BatCoV HKU10 which was also detected in Pomona roundleaf bats from the same country park suggests that these viruses may have the tendency of infecting genetically distant bat populations of close geographical proximity with subsequent genetic divergence. Moreover, the presence of SARSr-CoV ORF7a-like protein in Rs-BatCoV HKU32 suggests a common evolutionary origin of this accessory protein with SARS-CoV, also from Chinese horseshoe bats, an apparent reservoir for coronavirus epidemics. The emergence potential of Rs-BatCoV HKU32 should be explored.
Viruses
2019
Preimpreso
https://coronavirus.1science.com/item/b1bfcc04a269a982967a192b95f75b75723867b4
Inglés
VIRUS RESPIRATORIOS
Appears in Collections:Artículos científicos

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