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http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/120| Vitamin B12 and Risk of Diabetes: New insight from Cross-Sectional and Longitudinal Analyses of the China Stroke Primary Prevention Trial (CSPPT) | |
| Lishun Liu Yan Yang Wenhua Ling Youbao Li Xianhui Qin Genfu Tang Chengzhang Liu Jianping Li Yan Zhang Ping Chen Pierre A. Zalloua Xiao Huang Yong Huo Hao Zhang Xiping Xu Binyan Wang Yun Song Tengfei Lin Ziyi Zhou Zhuo Wang Yaping Wei Huiyuan Guo Xiaobin Wang | |
| Novel Coronavirus | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| 10.1101/2020.03.26.20044347 | |
| Introduction Previous studies in mostly Western populations, have yielded conflicting findings on the association of vitamin B12 with diabetes risk, in part, due to differences in study design and population characteristics. This study sought to examine the vitamin B12 and diabetes association in Chinese hypertensive adults by both cross-sectional and longitudinal analyses. Research Design and Methods This report included a total of 16699 participants from the China Stroke Primary Prevention Trial (CSPPT), with pertinent baseline and follow-up data. Diabetes mellitus (DM) was defined as either physician-diagnosed diabetes, the use of glucose-lowering drugs, or fasting blood glucose (FBG) ≥7.0 mmol/L. New-onset diabetes was defined as any new case of onset diabetes during the follow-up period or fasting blood glucose (FBG) ≥7.0 mmol/L at the exit visit. Results At baseline, there were 1872 (11.2%) diabetic patients; less than 1.5% had clinical B12 deficiency (<148.0 pmol/L). Over a median follow-up period of 4.5 years, there were 1589 (10.7%) cases of new-onset diabetes. Cross-sectional analyses showed a positive association between baseline vitamin B12 levels and FBG levels (β=0.18, 95%CI 0.15-0.21) and diabetes (OR=1.42, 95%CI 1.33-1.51). However, longitudinal analyses showed no association between baseline vitamin B12 and new-onset diabetes or changes in FBG levels. Among a subset of the sample (N=4366) with both baseline and exit B12 measurements, we found a positive association between an increase in B12 and an increase in FBG. Conclusions In this large Chinese hypertensive population mostly sufficient with vitamin B12, parallel cross-sectional and longitudinal analyses provided new insight into the conflicting findings of previous studies, and these results underscore the need for future studies to consider both baseline vitamin B12 and its longitudinal trajectory in order to better elucidate the role of vitamin B12 in the development of diabetes. Such findings, would have important clinical and public health implications. ### Competing Interest Statement Dr. Xiping Xu reports grants from the National Key Research and Development Program [2016YFE0205400, 2018ZX09739010, 2018ZX09301034003], the Science and Technology Planning Project of Guangzhou, China [201707020010], the Science, Technology and Innovation Committee of Shenzhen [JSGG20170412155639040, GJHS20170314114526143, JSGG20180703155802047], the Economic, Trade and Information Commission of Shenzhen Municipality [20170505161556110, 20170505160926390]. Dr. Youbao Li reports grants from the President Foundation of Nanfang Hospital, Southern Medical University [2017C007, 2018Z009]. Dr. Xianhui Qin reports grants from the National Natural Science Foundation of China [81730019, 81973133], Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University [2017J009]. Dr. Huiyuan Guo reports grants from the 111 project from the Education Ministry of China [No. B18053]. Dr. Xiao Huang reports grants from the National Natural Science Foundation of China [81960074, 81500233], Jiangxi Outstanding Person Foundation [20192BCBL23024], Major projects of the Science and Technology Department, Jiangxi [20171BAB205008] No other disclosures were reported. ### Funding Statement The study was supported by funding from the following: the National Key Research and Development Program [2016YFE0205400, 2018ZX09739010, 2018ZX09301034003], the Science and Technology Planning Project of Guangzhou, China [201707020010]; the Science, Technology and Innovation Committee of Shenzhen [JSGG20170412155639040, GJHS20170314114526143, JSGG20180703155802047]; the Economic, Trade and Information Commission of Shenzhen Municipality [20170505161556110, 20170505160926390]; the National Natural Science Foundation of China [81960074, 81500233, 81730019, 81973133]; President Foundation of Nanfang Hospital, Southern Medical University [2017C007, 2018Z009]; Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University [2017J009]; the 111 project from the Education Ministry of China [No. B18053] ; Jiangxi Outstanding Person Foundation [20192BCBL23024] and the Major projects of the Science and Technology Department, Jiangxi [20171BAB205008]. ### Author Declarations All relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript. Yes All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes All data included in this study are available upon request by contact with the corresponding author. | |
| Cold Spring Harbor Laboratory Press | |
| 2020 | |
| Preimpreso | |
| https://www.medrxiv.org/content/10.1101/2020.03.26.20044347v1 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
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