Por favor, use este identificador para citar o enlazar este ítem:
http://conacyt.repositorioinstitucional.mx/jspui/handle/1000/111| Early Spread of SARS-Cov-2 in the Icelandic Population | |
| Jona Saemundsdottir Asgeir Sigurdsson Patrick Sulem Gudmundur L Norddahl Pall Melsted Kari Stefansson Olafur T Magnusson Frosti Jonsson Kamilla S Josefsdottir Thordur Kristjansson Droplaug N Magnusdottir Louise le Roux Gudrun Sigmundsdottir Gardar Sveinbjornsson Kristin E Sveinsdottir Hakon Jonsson Maney Sveinsdottir Emil A Thorarensen Bjarni Thorbjornsson Arthur Love Gisli Masson Ingileif Jonsdottir Alma Moller Thorolfur Gudnason Karl G Kristinsson Unnur Thorsteinsdottir Aslaug Jonasdottir Brynjar O Jensson Hilma Holm Daniel F Gudbjartsson Berglind Eiriksdottir Run Fridriksdottir Elisabet E Gardarsdottir Gudmundur Georgsson Olafia S Gretarsdottir Kjartan R Gudmundsson Thora R Gunnarsdottir Arnaldur Gylfason Arna B Agustsdottir Agnar Helgason | |
| Novel Coronavirus | |
| Acceso Abierto | |
| Atribución-NoComercial | |
| 10.1101/2020.03.26.20044446 | |
| BACKGROUND Limited data exist on how SARS-CoV-2 enters and spreads in the general population. METHODS We used two strategies for SARS-CoV-2 testing: targeted testing of high-risk individuals (n=4,551) and a population screening (n=5,502). We sequenced SARS-CoV-2 from 340 individuals. RESULTS On March 22 2020, 528 had tested positive for SARS-CoV-2 in the targeted testing (11.6%) and 50 in the population screening (0.9%); approximately 0.2% of the Icelandic population. Large fractions of positives had travelled outside Iceland (38.4% and 34.0%). Fewer under 10 years old were positive than those older: 2.8% vs. 12.3% for targeted testing (P=1.6e-9) and 0.0% vs. 1.0% for population screening (P=0.031). Fewer females were positive in the targeted testing than males (9.5% vs. 14.6%, P=6.8e-9). SARS-CoV-2 came from eight clades, seven A clades and one B clade. The clade composition differed between the testing groups and changed with time. In the early targeted testing, 65.0% of clades were A2a1 and A2a2 derived from Italian and Austrian skiing areas, but in the later targeted testing went down to 30.6% and were overtaken by A1a and A2a, the most common clades in the population screening. CONCLUSION SARS-CoV-2 has spread widely in Iceland outside of the high-risk groups. Several strains cause these infections and their relative contribution changed rapidly. Children and females are less vulnerable than adults and males. To contain the pandemic we must increase the scope of the testing. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement No external funding. ### Author Declarations All relevant ethical guidelines have been followed; any necessary IRB and/or ethics committee approvals have been obtained and details of the IRB/oversight body are included in the manuscript. Yes All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes All sequenced virus genomes have been deposited into GISAID. | |
| Cold Spring Harbor Laboratory Press | |
| 2020 | |
| Preimpreso | |
| https://www.medrxiv.org/content/10.1101/2020.03.26.20044446v2 | |
| Inglés | |
| VIRUS RESPIRATORIOS | |
| Aparece en las colecciones: | Artículos científicos |
Cargar archivos:
| Fichero | Tamaño | Formato | |
|---|---|---|---|
| early spread of SARS COV.pdf | 1.73 MB | Adobe PDF | Visualizar/Abrir |