Please use this identifier to cite or link to this item: https://covid-19.conacyt.mx/jspui/handle/1000/1020
Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools
Fu, Y
Cheng, Y
Wu, Y
Acceso Abierto
Atribución-NoComercial-SinDerivadas
Currently there is no effective antiviral therapy for SARS-CoV-2 infection, which frequently leads to fatal inflammatory responses and acute lung injury. Here, we discuss the various mechanisms of SARS-CoV-mediated inflammation. We also assume that SARS-CoV-2 likely shares similar inflammatory responses. Potential therapeutic tools to reduce SARS-CoV-2-induced inflammatory responses include various methods to block FcR activation. In the absence of a proven clinical FcR blocker, the use of intravenous immunoglobulin to block FcR activation may be a viable option for the urgent treatment of pulmonary inflammation to prevent severe lung injury. Such treatment may also be combined with systemic anti-inflammatory drugs or corticosteroids. However, these strategies, as proposed here, remain to be clinically tested for effectiveness.
Virologica Sinica
2020
Preimpreso
https://coronavirus.1science.com/item/310868e7d43565d8053f699f082e10d52d5c4fe8
Inglés
VIRUS RESPIRATORIOS
Appears in Collections:Artículos científicos

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